Flexeril and tramadol Interactions Checker

Never crush or break a tramadol tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. You may have withdrawal symptoms if you stop using tramadol suddenly. You should be aware if anyone is using it improperly or without a prescription. Just one dose can cause death in someone using it accidentally or improperly.

  • The incidence can be significantly increased if these drugs are overdosed or taken together.
  • This drug has been shown to be excreted in rat milk and achieve concentrations in the milk which are 50% of those in the rat maternal plasma.
  • This drug can increase prolactin levels; however, the prolactin level in a mother with established lactation may not affect her ability to breastfeed.
  • When tramadol is used for a long time, it may become habit-forming, causing mental or physical dependence.
  • Your condition will not improve any faster, and your risk of side effects will increase.
  • Bayview Pharmacy is proud to offer Tramadol HCl 5%/Lidocaine 5%/Cyclobenzaprine HCl 2%/Diclofenac Sodium 5%/Menthol 1%/DMSO Topical Lipoderm Activemax®.

Cyclobenzaprine is a skeletal muscle relaxant and a depressant of the central nervous system. As a muscle relaxant it is used together with physical therapy and other measures for relaxing muscles and relieving pain and discomfort that can be caused by sprains, strains, and different muscle injuries. You should avoid taking tramadol and Flexeril together unless specifically directed by your doctor as the drugs have a potentially significant interaction. In our latest question and answer, our pharmacist discusses whether or not there is a drug interaction between tramadol and Flexeril (cyclobenzaprine).

Do not take this drug for more than 3 weeks without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor. Tramadol is a centrally-acting analgesic indicated for moderate to severe pain.1 It stimulates opioid receptors, and inhibits noradrenaline and serotonin reuptake.

Drug and Pregnancy Interactions

Dizziness or drowsiness can cause falls, accidents, or severe injuries. It works by blocking the reuptake of the “feel good” neurotransmitters norepinephrine and serotonin that regulate mood. In other words, it can increase serotonin levels in the brain, as well as norepinephrine. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction.

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According to European League Against Rheumatism, it is recommended for the treatment of chronic pain caused by medical condition called fibromyalgia. The patient subsequently developed uncontrollable anxiety and clenching of her left hand. The patient called her psychiatrist to inquire if it might be related to her taking Effexor, but her psychiatrist said the patient’s symptoms were unlikely to be side effects of the drug.


If a nursing mother is an ultra-rapid metabolizer of tramadol, it could lead to an overdose in the nursing baby and cause very serious side effects. Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken with or without food three times a day. The extended-release capsule is usually taken with or without food once a day.

Seizures and serotonin syndrome are amongst the more commonly reported serious adverse reactions attributed to tramadol in the CARM and the WHO International Drug Monitoring databases. Tramadol HCl 5%/Lidocaine 5%/Cyclobenzaprine HCl 2%/Diclofenac Sodium 5%/Menthol flexeril and blood pressure 1%/DMSO Topical Lipoderm Activemax® is a topical formulation used to treat a variety of musculoskeletal conditions. Tramadol HCl is an opioid analgesic that works to reduce pain. Lidocaine is a local anesthetic that works to reduce pain and inflammation.

Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval. Alcohol can increase the nervous system side effects of cyclobenzaprine such as dizziness, drowsiness, and difficulty concentrating.

If you notice any other effects, check with your healthcare professional. Both tramadol and Flexeril can provide effective pain relief when used as prescribed by your healthcare provider, but combining these medications should only be done under their supervision. For most patients, the recommended dose of Flexeril is 5 mg three times a day.